Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 26: Posters - Cell Adhesion

BP 26.7: Poster

Dienstag, 21. März 2017, 14:00–16:00, P2-EG

Microbial adhesion forces on nanostructured surfaces — •Carolin Dewald^1,2,3, Claudia Lüdecke-Beyer¹, Martin Roth^2,3, Jörg Bossert¹, and Klaus D. Jandt^1,3 — ¹Chair of Materials Science, Otto Schott Institute of Materials Rsesearch, Friedrich Schiller University Jena, Löbdergraben 32, 07743 Jena — ²Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute Jena, Beutenbergstraße 11, 07745 Jena — ³Jena School for Microbial Communication, Neugasse 23, 07743 Jena

Often only qualitative adhesion properties are analyzed limiting the quantitative information about adhesion forces between microbial cells and materials surfaces. Force-distance curves are one option to measure adhesion forces. Therefore, the aim of this study is to investigate the adhesion kinetics and forces of Candida albicans as function of nanoparticle structured materials surfaces. The investigated surfaces with different AuNPs densities as well as unstructured control surfaces showed no statistically significant differences in contact angle and surfaces chemistry. A reduced microbial adhesion was observed on the nanostructured surfaces compared to the control surface. The AuNPs act as contact points for initial microbial adhesion which was confirmed by force-distance curves. A lower AuNP density led to a reduced microbial adhesion due to reduced adhesion forces between microbial cells and materials surfaces. This study will provide new insight into microbial adhesion on materials surfaces structured in the nanometer range.