Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 29: Posters - Multi-Cellular Systems
BP 29.10: Poster
Dienstag, 21. März 2017, 14:00–16:00, P2-EG
Mode structure of morphogen transport — •Daniel Aguilar-Hidalgo1,2, Maria Romanova-Michaelides2, Marcos González-Gáitan2, and Frank Jülicher1 — 1Max Planck Institute for the Physics of Complex Systems — 2University of Geneva
Concentration profiles of specific signaling molecules, also called morphogens, have been identified that control patterning and growth of developing tissues. In this regard, the morphogen transport dynamics defines the shape of the morphogen profile, which has been highlighted as a key factor in a number of growth control mechanisms, hence the importance to understand how molecules are transported in tissues. We propose a general theoretical framework and a novel approach for the study of morphogen transport dynamics in cell monolayer tissues. In particular, we analyze the mode structure of a transport model, where we allow molecules to spread by free diffusion and transcytosis that is a trafficking process in which molecules travel long distances by subsequent rounds of internalization and externalization at different positions in cells. Our theory reveals different transport modes in the system. We discuss how seemingly contradictory interpretation of experiments that measure morphogen transport dynamics (FRAP, FCS) may capture different dynamical modes in the system. Our theoretical framework allows quantifying effective transport parameters as well as rates for elementary transport events, unifying measures from different experimental assays. As a particular case of study, we apply our theory to quantitatively describe the transport of the morphogen Dpp in the Drosophila wing disc.