Dresden 2017 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 35: Posters - Physics of Parasites (Focus Session)

BP 35.1: Poster

Dienstag, 21. März 2017, 14:00–16:00, P2-OG1

Monitoring the blood-stage infection and hemozoin clearance in malaria rodent models by a novel malaria diagnostic device — •Maria Pukancsik1, Agnes Orban1, Petra Molnar1, Adam Butykai1, Maria Rebelo2, Thomas Hanscheid2, Ahmed S I Aly3, and Istvan Kezsmarki11Dept. of Physics, Budapest University of Technology and Economics and MTA-BME Lendület Magneto-optical Spectroscopy Research Group,1111 Budapest, HU — 2Instituto de Medicina Molecular, Faculdade de Medicina, Lisbon, PO — 3Tulane University, Dept. of Tropical Medicine, New Orleans, USA

The first prototype of a diagnostic device was developed as a sensitive platform for malaria diagnosis. The rotating-crystal magneto-optical diagnostic technique (RMOD) targets the natural biomarker hemozoin, which is a magnetic microcrystalline heme compound produced by all species of malaria parasites such as Plasmodium falciparum and Plasmodium vivax. The in vivo investigation of the RMOD device was performed using P. falciparum-like and P. vivax-like species of malaria parasites infecting mice (e.g. P. berghei, P. chabaudi, P. yoelii, P. vinckei) in collaboration with the Instituto de Medicina Molecular and with the Department of Tropical Medicine at Tulane University. The lethal and non-lethal rodent malaria parasites that model different human strains and characteristics of the human blood stage were used in order to monitor the onset of the blood stage infection and compare the sensitivity of the device depending on the rodent strains. The hemozoin clearance was also monitored in vivo during and following the drug treatment of infected mice.

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