Dresden 2017 – wissenschaftliches Programm
BP 6.1: Hauptvortrag
Montag, 20. März 2017, 15:00–15:30, SCH A251
Quantifying and modelling active motion in biological systems — •Timo Betz — Institute of Cell Biology, ZMBE, University Münster, Germany
Living biological systems are continuously reorganizing their structure to perform their function. The mechanical activity plays here an important role, as the constant generation of forces drives fluctuations as well as controlled motion of intracellular particles, membranes and cells. From a physical point of view, this active motion drives the system far away from thermodynamic equilibrium, which can be measured as a violation of equilibrium quantities such as the fluctuation dissipation theorem.
Quantifying the out-of-equilibrium components provides the possibility to model the active molecular processes. We measure the energy and the forces actively applied on membranes as well as cellular granules and model these with an active Langevin approach. By comparing the predictions of forces and mechanics with the measurement of the fluctuations and viscoelastic properties we can extract molecular parameters from mesoscopic measurements. This gives timescales and chemical reaction parameters such as forces, binding states and velocities of the underlying proteins using a simple average measurement of the active motion.