Dresden 2017 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 60: Physics of Parasites - Joint Focus Session (BP/DY) organized by Holger Stark
BP 60.1: Hauptvortrag
Freitag, 24. März 2017, 09:30–10:00, SCH A251
Spontaneous curvature and membrane curling for malaria-infected erythrocytes — •Manouk Abkarian1,2, Octavio Albarran Arriagada2, Gladys Massiera2, Cyril Claudet1,2, Andrew Callan Jones2, Vladimir Lorman2, and Catherine Braun Breton3 — 1Centre de Biochimie Structurale, Montpellier, France — 2Laboratoire Charles Coulomb, Monptellier, France — 3Dynamique des Interactions Membranaires Normales et Pathologiques, Montpellier, France
The culminating step of the intra-erythrocytic development of P. falciparum, the causative agent of malaria, is the spectacular release of multiple invasive merozoites upon rupture and curling of the infected erythrocyte membrane in a split second. We rationalized curling eversion by the acquisition of a high (negative) natural curvature c0 by the iEM, at a moment during parasite development. In this presentation, we will discuss our current investigation on curling both experimentally and theoretically. In particular, we will show with recent data that c0 is acquired several hours before maturation, by inducing a metastable curled and opened pore state in the iEM. I will discuss such stability using a more sophisticated model of the iEM taking into account its axisymmetry, the pore line tension and the iEM shear elasticity. Our model captures such a metastability and predicts the dynamics during egress when considering the internal and external viscous dissipations of the iEM. In particular, our approach underlines the importance of the membrane viscous flow thanks to the study of macroscopic elastic naturally curved ribbons.