Dresden 2017 – wissenschaftliches Programm
CPP 2.2: Vortrag
Montag, 20. März 2017, 10:00–10:30, SCH A251
Quantitative structure-function relationships in 3D tissues — •Janna Nawroth — Emulate Inc., Boston, MA, USA
Biological tissues are characterized by an organ-specific three-dimensional, multiscale organization of cells and extracellular matrix components. This organization gives rise to organ-specific functions and dysfunctions. Tissue engineering attempts to recapitulate these structure-function relationships in vitro to provide models of disease, drug toxicity, and patient-specific responses. One major challenge is to identify and implement quantitative metrics that capture the most relevant structure-function relationships to serve for both quality control and experimental readout of the engineered tissue. Here, I present engineering and analysis strategies for recapitulating and quantifying the cellular organization and mechanical functions in engineered cardiac muscle and in ciliated epithelia, with a particular emphasis on organ-on-chip technology.