Dresden 2017 – wissenschaftliches Programm
CPP 2.7: Vortrag
Montag, 20. März 2017, 12:00–12:15, SCH A251
Local rules for robust global transport in liver networks — •Jens Karschau1, Andre Scholich2, Marius Asal1, Hidenori Nonaka3, Hernan Morales-Navarrete3, Fabian S Miranda3, Kirstin Meyer3, Yannis Kalaidzidis3, Marino Zerial3, Frank Jülicher2, and Benjamin M Friedrich1 — 1cfaed / TU Dresden — 2MPI PKS, Dresden — 3MPI CBG, Dresden
The liver represents a chemical factory that is characterised by intertwined transport networks for toxins and metabolites. Each hepatocyte cell of the liver tissue interacts with two space-filling networks: bile canaliculi and sinusoids which transport bile and blood, respectively. How these networks establish their distinct architecture to supply all hepatocytes, and dynamically adapt to time-varying load as well as to local perturbations remains elusive.
Here, we elucidate design principles of liver tissue structure and self-organisation based on experimental high-resolution imaging data from mice. First, we characterise and quantify liver tissue with tools from liquid-crystal theory that show lobule level patterns of aligned cell polarity and local network anisotropy. Second, we study a simplified flow model to understand the relationship between the spatial structure of the network and robust transport properties. Third, we compare our flow simulations in reconstructed bile canaliculi networks and simulated self-organised networks. Thereby, we establish a connection between local network geometry and properties of global fluid transport, linking tissue structure with function.