Dresden 2017 – wissenschaftliches Programm
CPP 2.8: Vortrag
Montag, 20. März 2017, 12:15–12:30, SCH A251
Jamming and liquidity in 3D cancer cell aggregates — Linda Oswald1, •Steffen Grosser1, Jürgen Lippoldt1, Steve Pawlizak1, Anatol Fritsch2, and Josef Käs1 — 1University of Leipzig — 2MPI CBG Dresden
Traditionally, tissues are treated as simple liquids, which holds for example for embryonic tissue. However, recent experiments have shown that this picture is insufficient for other tissue types, suggesting possible transitions to solid-like behavior induced by cellular jamming. The coarse-grained self-propelled Voronoi (SPV) model predicts such a transition depending on cell shape which is thought to arise from an interplay of cell-cell adhesion and cortical tension. We observe non-liquid behavior in 3D breast cancer spheroids of varying metastatic potential and correlate single cell shapes, single cell dynamics and collective dynamic behavior of fusion and segregation experiments via the SPV model.