Dresden 2017 – wissenschaftliches Programm
CPP 4.9: Vortrag
Montag, 20. März 2017, 12:45–13:00, ZEU 114
Theoretical quantification of nano carrier loading and release rates — •Richard Schwarzl1, Fang Du2, Rainer Haag2, and Roland R. Netz1 — 1Freie Unversität Berlin, Fachbereich Physik, Arnimallee 14, 14195 Berlin — 2Freie Unversität Berlin, Institut für Chemie und Biochemie, Arnimallee 14, 14195 Berlin
Macromolecular nanostructures that are used as drug carriers are characterized by their loading and release kinetics. Release studies commonly employ the dialysis method, in which a cellulose membrane separates the solution of released drug from the nanocarrier solution. In order to extract the nano carrier release rate, it is necessary to take the effect of the dialysis membrane on the release kinetics into account. Using a theoretical two-step approach, consisting of the analysis of a calibration experiment of drug diffusion through the dialysis membrane in the absence of nanocarriers, and of an experiment in the presence of nanocarriers, one is able to determine all kinetic rates and in particular to disentangle kinetic dialysis membrane properties from kinetic nanocarrier properties.