Dresden 2017 – wissenschaftliches Programm
CPP 45.1: Vortrag
Mittwoch, 22. März 2017, 15:00–15:15, SCH A251
The microstructural function of the tendon-bone insertion — •Leone Rossetti1, Lara A. Kuntz1,2, Elena Kunold3, Jonathan Schock1, Kei W. Müller4, Heinrich Grabmayr1, Josef Stolberg-Stolberg5, Franz Pfeiffer1, Stephan A. Sieber3, Rainer Burgkart2, and Andreas R. Bausch1 — 1Physik Department,TU München,D-85748 Garching, Germany — 2Klinik für Orthopaedie und Sportorthopaedie, Klinikum rechts der Isar, TU München, D-81675 München, Germany — 3CIPSM, Department of Chemistry, TU München, D-85747 Garching, Germany — 4Institute for Computational Mechanics , TU München, D-85748 Garching, Germany — 5University Hospital Münster, D-48149 Münster, Germany
The exceptional mechanical properties of the connection of tendon to bone rely on an intricate interplay of its biomolecular composition, microstructure and micromechanics. Here we identify that the Achilles tendon insertion is characterized by a stress reducing mechanism within an interfacial zone of 500 micrometres, with a distinct fiber organisation and biomolecular composition. Proteomic analysis detects enrichment in the interface region that are predominantly involved in cartilage and skeletal development as well as proteoglycan metabolism. Micromechanical testing coupled with multiscale confocal microscopy identifies a heterogenous mechanical response in the interface area, endowing the enthesis with a graded response to strains acting from different angles. The presented mechanisms mark a guideline for further biomimetic strategies to rationally design hard-soft interfaces.