Dresden 2017 – wissenschaftliches Programm
CPP 49.4: Poster
Mittwoch, 22. März 2017, 18:30–21:00, P2-OG1
Adsorption Simulations of Plasma Proteins on Silica Surfaces — •Timo Schäfer1,2, Giovanni Settanni1,3, and Friederike Schmid1 — 1Johannes Gutenberg-University Mainz — 2Graduate School Materials Science in Mainz — 3Max Planck Graduate Center with the Johannes Gutenberg-University Mainz
Nanoparticle based therapeutics are a topic of ongoing research, promising effective use as drug delivery systems that shield aggressive and/or fragile drugs while transporting them to a target location inside the body. One of the major challenges in their application is the formation of a layer of adsorbed plasma proteins as soon as the nanoparticle enters the blood stream. This so-called protein corona can significantly impair the nanoparticle's functionality such as active targeting or enhancement of blood circulation times. While the corona formation can be limited, existing techniques cannot completely prevent it, and molecular details of the underlying mechanism are largely unknown. Here, we study the early adsorption of plasma proteins onto the surface of a silica nanoparticle using classical atomistic molecular dynamics simulations. Using a sophisticated silica surface model, adsorption dynamics, interaction patterns and the impact of the adsorption on protein structure and functionality are analyzed.