Dresden 2017 – wissenschaftliches Programm
CPP 52.5: Poster
Mittwoch, 22. März 2017, 18:30–21:00, P3
In-situ soft X-ray analysis of various polymer-based microcontainers for theranostic and catalytic applications — •Andreas Späth1, Gaio Paradossi2, George Tzvetkov3, and Rainer H. Fink1 — 1Friedrich-Alexander Universität Erlangen-Nürnberg, Lehrstuhl für Physikalische Chemie II and ICMM, Erlangen, Germany — 2Universita di Roma Tor Vergata, Dipartimento di Scienze e Tecnologie Chimiche, Rome, Italy — 3University of Sofia, Department of Inorganic Chemistry, Sofia, Bulgaria
Polymer-based microshells and microgel particles are versatile containers for the transport of drugs, theranostic gases or catalytically active molecules. They are in many cases biodegradable and fully compatible to in-vivo applications. During recent years we have investigated a broad range of such hybrid materials ranging from gas filled microballoons and thermoresponsible microgel networks to magnetoresponsive particles with embedded iron nanoparticles and core-shell systems with various fillings, e.g., ionic liquids [1-3]. Soft X-ray microscopy is an excellent tool to study those systems in-situ in aqueous matrix with high-resolution and chemical sensitivity. We have analyzed shell thicknesses, swelling behaviors and responses to temperature increase to contribute better understanding on release mechanisms, have developed procedures to derive 3D representations of the particles from originally 2D transmission micrographs.
 A. Späth et al., Ultramicroscopy, 2014, 144, 19.
 A. Späth et al., RSC Advances, 2014, 4, 3272.
 A. Späth et al., RSC Advances, 2016, 6, 98228.