Dresden 2017 – wissenschaftliches Programm
CPP 6.2: Vortrag
Montag, 20. März 2017, 10:45–11:00, ZEU 160
A new look at blood shear-thinning — Luca Lanotte1, Johannes Mauer2, Simon Mendez3, Dmitry Fedosov2, Jean-Marc Fromental4, Viviana Claveria1, Franck Nicoud3, Gerhard Gompper2, and •Manouk Abkarian1 — 1Centre de Biochimie Structurale, Montpellier, France — 2Institute of Complex Systems and Institute for Advanced Simulation, Forschungszentrum Jülich, Germany — 3Institut Montpelliérain Alexander Grothendieck, Montpellier, France — 4Laboratooire Charles Coulomb, Montpellier, France
Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear-thinning is intimately related to the dynamics and mutual interactions of red blood cells (RBCs), the major component of blood. Because of the lack of knowledge about their behavior under physiological conditions, the link between RBCs dynamics and blood rheology remains still unsettled. Performing experiments and simulations in microcirculatory flow conditions of viscosity, shear rates and volume fractions, our work reveals how rich RBCs dynamic morphologies govern blood shear thinning, contrary to the current paradigm assuming steady RBC orientation and membrane circulation. Our results suggest that any pathological change in RBCs* local rheology will impact the onset of these morphological transitions and should play a key role in pathological blood flow.