Dresden 2017 – wissenschaftliches Programm
CPP 6.4: Vortrag
Montag, 20. März 2017, 11:15–11:30, ZEU 160
Margination of blood cells — •Revaz Chachanidze1,2, Marc Leonetti1, and Christian Wagner2 — 1Institut de Recherche sur les Phénomènes Hors Equilibre (I.R.P.H.E), Aix-Marseille University, Marseille, France — 2Saarland University, Saarbruken, Germany
In blood flow erythrocytes migrate to the centre of the vessel creating a *cell-free layer* at the edge while leucocytes, lymphocytes and platelets tend to migrate to vessel walls. This phenomenon is known as margination. Margination of leucocytes and its role in immune response as well as margination of red blood cells in cases of some diseases (such as malaria and sickle cell disease) have been subjects of research for a while. Recent advances in targeted drug delivery arouses interest to margination of micro- and nano-particles.
Our research is dedicated to better understanding of mechanical properties of particles involved in margination and to create conditions for blood flow under which particles manifest tendency to segregation. For this purposes we observe and quantify blood flow consisting of 2 populations of red blood cells * healthy and rigidified with cross-linking agent (glutaraldehyde) * in microfluidic channels in cases of different volumetric flow rate, cells concentration and etc.