Dresden 2017 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 27: Posters - Statistical Physics Biological Systems
DY 27.5: Poster
Dienstag, 21. März 2017, 18:15–21:00, P3
Receptor activation — •Cheng-Yu Sun1 and Hsuan-Yi Chen1,2 — 1Department of Physics, Nation Central University, Taoyuan 32001, Taiwan — 2Institute of Physics, Academia Sinica, Taipei 11520, Taiwan
To effectively detect external environment, receptors in biological cells have to be sensitive and efficient. In this study, we consider a general receptor activation model. In our model, a binding site can bind to a ligand, it can also be activated by an activator. Depending on its binding and activation state, a binding site has four states. We allow couplings between sites through their binding states and activation states. The equilibrium study reveals that strong switch-like behavior can be achieved by strong coupling of the activation states between the sites, while the additional coupling of the binding state helps to strengthen this effect. We also study the dynamics of coupled sites. The results show the important role played by the ratio between binding rate and activation rate. The regions where the behavior of this system becomes similar to classical MWC and Pauling models are discussed.