Dresden 2017 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 27: Posters - Statistical Physics Biological Systems
DY 27.6: Poster
Dienstag, 21. März 2017, 18:15–21:00, P3
A minimal spatial cell lineage model of epithelium exhibits tissue stratification and multi-stability — Wei-Ting Yeh1 and •Hsuan-Yi Chen1,2 — 1Department of Physics, National Central University, Jhongli, 32001, Taiwan — 2Institute of Physics, Academia Sinica, Taipei, 11529, Taiwan
In this work, we consider stratified epithelium, which is a multi-layered self-renewal tissue, and build up a minimal model which includes the spatial information and cell lineage dynamics. We numerically and analytically solve the steady state and discuss how different differentiation models can lead to different tissue functionality and stratification. Thus, we provide a possible way to deduce the unknown cell differentiation mechanism by fitting the observed degree of stratification with our model.
The minimal model also shows other properties. For example, we find that there is no stratified steady state if there is only short-range interaction between cells. In other word, we need long-range interaction like coupling with morphogen dynamics to avoid the trivial homogeneous state. Interestingly, our model in general permits the existence of multiple steady states if both long- and short-range interaction between cells are present, and the degree of functionality and stratification is different for each steady state. In the future, it is possible to study the transition between these states and discuss its biological relevance to tissue morphogenesis and cancer invasion.