Dresden 2017 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 43: Nonlinear Dynamics, Synchronizsation and Chaos
DY 43.10: Vortrag
Donnerstag, 23. März 2017, 12:00–12:15, ZEU 118
Impact of anisotropy on termination of pinned spiral waves using far field pulses — •Edda Boccia1, Stefan Luther1,2,3, and Ulrich Parlitz1,3 — 1Max Planck Institute for Dynamics and Self-Organization, Göttingen, Germany — 2Department of Pharmacology, University Medical Center, Göttingen, Germany — 3Institute for Nonlinear Dynamics, Georg-August-Universität Goettingen, Göttingen, Germany
Reentrant waves find a critical substrate in the multi-sized heterogeneities of myocardium. Spiral waves pinned to an heterogeneity can self-terminate or be unpinned (and terminated) by electric far field pulses exploiting heterogeneities as virtual electrodes. We implement a 2D bidomain formulation of the phase I of the Luo and Rudy model under acute ischemia. We investigate how anisotropy and size of the ischemic area may affect reentrant dynamics with and without exposing the tissue to far field pacing (FFP). Without FFP, we found that: 1. waves stability is affected more by changes in the intracellular space than by modifications in the extracellular space; 2. not only the size of the heterogeneity, but also the degree of intracellular anisotropy highly affects maintenance or self-termination of pinned spirals. How FFP contributes to unpinning or successful termination of pinned spirals in anisotropic media is much less clear compared to isotropic domains. In this contribution we focus on the impact of anisotropy and compare the success rate for several sequences of FFP pulses in both isotropic and anisotropic domains. Interestingly, anisotropic tissues result to be a more suitable substrate for successful termination of pinned spirals.