Dresden 2017 – wissenschaftliches Programm
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MM: Fachverband Metall- und Materialphysik
MM 22: Poster session I
MM 22.20: Poster
Montag, 20. März 2017, 19:00–20:00, P4
Multiplexed sensing of small molecules with silicon nanowire field effect transistors — •Stephanie Klinghammer1, Tetiana Voitsekhivska2, Clemens Kirschbaum3, Larysa Baraban1, and Gianaurelio Cuniberti1,4 — 1Institute for Materials Science and Max Bergmann Center of Biomaterials, TU Dresden, 01062 Dresden, Germany — 2Institute of Electronic Packaging Technology, TU Dresden, 01062 Dresden, Germany — 3Department of Psychology, TU Dresden, 01062 Dresden, Germany — 4Center for Advancing Electronics Dresden, TU Dresden, 01062 Dresden, Germany
The simultaneous detection of multiple targets within a single chip on a point-of-care device is attracting great attention within bio- and nanotechnology areas for more than decade[1]. Here, we demonstrate a multiplexed, label-free and real-time detection platform for small molecules like hormones, steroids, and viruses based on silicon nanowire field effect transistors (SiNW FETs). SiNW FETs are connected to a CMOS chip enabling the simultaneous readout of up to 32 FETs [2]. We particularly focus on the sensitive and selective binding of the target cortisol by using aptamers as receptors - allowing high sensitive screenings in more physiological conditions[3]. Finally we show the working principle in form of the biochipboxwhich serves as a portable, electro-microfluidic device facilitating the versatile and reliable detection of multiple samples on only one single sensor device. (1) Patolsky, F. et al., Nanomed. 2006, 1 (1), 51-65.; (2) Voitsekhivska, T. et al., IEEE, 2014; pp 173-178.; (3) Römhildt, L. et al., ACS Appl. Mater. Interfaces 2013, 5 (22), 12029-12035.