Dresden 2017 – wissenschaftliches Programm
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TT: Fachverband Tiefe Temperaturen
TT 36: Brownian Motion (jointly with DY)
TT 36.2: Vortrag
Dienstag, 21. März 2017, 10:15–10:30, ZEU 147
The transient subdiffusive behavior of particles in mucus — •Thomas John1, Matthias Ernst2, Marco Günther2, Ulrich Schäfer3, Christian Wagner1, and Claus-Michael Lehr4 — 1Experimental Physics, University of Saarland — 2Faculty of Engineering, University of Applied Sciences, Saarbrücken — 3Helmholtz Institute for Pharmaceutical Research Saarland — 4Biopharmaceutics and Pharmaceutical Technology, University of Saarland
Biological barriers are crucial in protecting our body from environmental influences. Well-known outer barriers are intestinal, pulmonary, nasal, buccal, cervico-vaginal and dermal barriers. Except for the dermal barrier, all these are covered by a mucus layer, providing an additional barrier to the epithelial cell layer.
We have applied a model to explain the reported subdiffusion of particles in mucus, based on the measured mean squared displacements (MSD). The model considers Brownian diffusion of particles in a confined geometry, made from permeable membranes. The applied model predicts a normal diffusive behavior at very short and long time lags, as observed in several experiments. In between these time scales, we find that the "subdiffusive" regime is only a transient effect, MSD∝ τα , α<1. The only parameters in the model are the diffusion-coefficients at the limits of very short and long times, and the distance between the permeable membranes L. Our numerical results are in agreement with published experimental data for realistic assumptions of these parameters.
This work was submitted and accepted in the Biophysical Journal.