Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 15: Postersession III
BP 15.72: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster B
Optogenetic modeling of murine ventricular cardiomyocytes — •Sayedeh Hussaini1,2, Claudia Richter1,4, and Stefan Luther1,2,3 — 1RG Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, Goettingen, Germany — 2Institute for Nonlinear Dynamics-Georg-August Goettingen University, Goettingen, Germany — 3University Medical Center Goettingen (UMG), Department of Pharmacology and Toxicology, Goettingen, Germany — 4University Medical Center Goettingen (UMG), Department of Cardiology and Pneumology, Goettingen, Germany
Current arrhythmia treatments applying high energetic electrical shocks still present severe side effects such as tissue damage due to electroporation hence worsening the prognosis. Optogenetics is a new method that enables selective photo-optical stimulation of the heart. Therefore, computational modeling can be of specific interest to predict changes in cardiac action potentials. However, in silico studies have been mainly implemented concentrating on human specific parameters ignoring the fact that the majority of experimental research projects are done in animal models. Because of this discrepancy, we successfully implemented the light-activated ion channel Channelrhodopsin-2 in an ionic model of murine ventricular cardiomyocytes (Bondarenko model). Ongoing work includes extending this single cell model into two dimensions. Results of the computational study are used to optimize and validate current experiments on transgenic mouse hearts. All results will be discussed in comparison to conventional electrical stimulation.