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BP: Fachverband Biologische Physik
BP 15: Postersession III
BP 15.80: Poster
Tuesday, March 13, 2018, 14:00–16:00, Poster B
Modelling the motility of Cytotoxic T Lymphocytes inside infected lymph nodes — •Zeinab Sadjadi1,2, Michael Meyer- Hermann2, and Stephan Halle3 — 1Theoretical Physics, Sarrland University, 66123 Saarbrücken, Germany — 2Helmholtz Center for Infection Research, 38124 Braunschweig, Germany — 3Hannover Medical School, 30625 Hannover, Germany
Cytotoxic T Lymphocytes detect and kill infected cells in lymph nodes. The underlying mechanisms of this process are however still unclear. The results of 2-photon microscopy experiments in vivo have shown different migration patterns and processivities of CTLs during search and killing processes[1]. We aim to understand the possible roles of chemotaxis, T cells cooperativity during killing, and fibroblastic reticular network on the dynamics and search strategy of CTLs inside a lymph node. We develop a persistent random walk model for the motion of CTLs during search and killing phases which enables us to study the role of key parameters on search efficiency and killing.
[1] Nature Reviews Immunology 16, 193-201 (2016)