Berlin 2018 – scientific programme

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BP: Fachverband Biologische Physik

BP 15: Postersession III

BP 15.98: Poster

Tuesday, March 13, 2018, 14:00–16:00, Poster B

MT-bundling activity of the MKLp2 kinesin — •Amna Abdalla Mohammed Khalid¹, I-Mei Yu², Anne Houdusse², and Christoph F. Schmidt¹ — ¹Drittes Physikalisches Institut - Biophysik, Fakultät für Physik, Georg-August-Universität Göttingen, Germany — ²Institut Curie Paris, France

The Kinesin-6 MKLP2 motor is N-terminal Kinesin, with unique features. It plays critical roles in cell division. Scientists know little about MKLP2; however, few earlier findings suggested that MKlp2 is a good candidate for new cancer therapies. To gain insight into the motor regulation and mechanism, we are studying truncated MKLP2. Here, I present the studies of a dimeric truncated MKlp2, in vitro using fluorescence microscopy. Our data confirm that the dimeric truncated MKlp2 motors are active and they display strong bundling activity. An astonishing finding, we observed the formation of novel three-dimensional microtubule-MKLP2 construct(s) networks with unique properties.