Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 17: Cell Mechanics I
BP 17.11: Vortrag
Mittwoch, 14. März 2018, 12:45–13:00, H 1058
Treatment of cancer cells with acoustic waves — •Maja Strugacevac1, Nina Bartels1, Tobias Löffler1, Constanze Wiek2, Marcel Glaas2, Jörg Schipper2, and Mathias Getzlaff1 — 1Heinrich-Heine-Universität Düsseldorf, Institute of Applied Physics, Düsseldorf, Germany — 2Düsseldorf University Hospital, Department of Otorhinolaryngology, Düsseldorf, Germany
Our group is developing new, alternative, cell-selective treatment strategies for squamous cell carcinoma of the head-neck area based on the different mechanical properties of oral keratinocytes and cancer cells. As a first step we compared their cytoskeleton and observed the differences in actin filaments and microtubules, both playing a significant role in cell elasticity. Oral keratinocytes are differently formed and seem to contain more fibers then cancer cells which could lead to the conclusion that there is a difference in cytoskeleton between this cell types.
In a second step we have irradiated different cell lines with acoustic waves exhibiting frequencies from 0.5 up to 10 kHz. Using different frequencies and input power we investigated the behavior of the cells exposed to the sound waves. Our latest results will be presented and discussed.