Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 28: Single Molecule Biophysics
BP 28.8: Vortrag
Donnerstag, 15. März 2018, 11:45–12:00, H 1058
DNA strand break yields by OH-radicals, low energy electrons and prehydrated electrons — •Marc Benjamin Hahn1,2, Tihomir Solomun2, and Heinz Sturm2,3 — 1Freie Universität Berlin — 2Bundesanstalt für Materialforschung und -prüfung — 3Technische Universität Berlin
Radiation damage to biomolecules such as DNA, is the reason to treat cancer via radiation therapy. The understanding of the molecular processes and the quantification of the underlying damaging mechanisms is necessary to develope more efficient irradiation protocols for cancer therapy. Thereby damage to DNA is of key interest due to its central role in reproduction and mutation. Due to the high amount of water in biological tissue, most of the damage is caused by the secondary particles which are produced by the interaction of ionizing radiation with water. Thereby a multitude of species are produced, e.g. kinetic low energy electrons, prehydrated electrons, OH-radicals and ions. The quantification of the contribution to DNA damage by the various species is of interest. Here we present an experimental approach to disentangle their relative DNA strand break yields. Plasmid DNA (pUC19) is irradiated in water with electrons under the presence of different scavengers. The presented preliminary results reveal the relative contributions of OH-radicals, low energy electrons and prehydrated electrons and their DNA single and double strand break yields.