Berlin 2018 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 29: Statistical Physics of Biological Systems I (joint session BP/DY)

BP 29.11: Vortrag

Donnerstag, 15. März 2018, 12:30–12:45, H 2013

Chemoattractant induced transient adaptation in the oscillatory cytoskeleton of motile amoeboid cells. — •Jose Negrete JR^1,2, Alain Pumir^3,4, Christian Westendorf⁴, Marco Tarantola⁴, Eberhard Bodenschatz^4,5,6, and Carsten Beta⁷ — ¹Max Planck Institute for the Physics of Complex Systems, Dresden, Germany — ²École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland — ³École Normale Supérieure de Lyon, Lyon, France — ⁴Max Planck Institute for Dynamics and Selforganization — ⁵University of Göttingen, Göttingen, Germany — ⁶Cornell University, Ithaca, USA — ⁷University of Potsdam, Potsdam, Germany

Dictyostelium discoideum presents oscillatory actin polymerization cycles which amplitude is mostly given by noise. We investigate the transient response on the actin polymerization activity in Dictyostelium discoideum induced by a short pulse of cAMP. The stimulation induces a transient response, of reduced amplitude and frequency, which time duration is stochastic and varies between cells. To model the observed actin behavior, we extend the description of noisy oscillator by introducing an inhibitory variable that acts as a timer for the transient phase.