Berlin 2018 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 34: Neuroscience
BP 34.7: Vortrag
Donnerstag, 15. März 2018, 16:45–17:00, H 1058
Interkinetic nuclear migration as a stochastic process in the zebrafish retina — •Anne Herrmann1, Afnan Azizi2, Salvador J. R. P. Buse2, Yinan Wan3, Philipp J. Keller3, William A. Harris2, and Raymond E. Goldstein1 — 1Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom — 2Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom — 3Howard Hughes Medical Institute, Janelia Research Campus, Ashburn, VA, USA
In recent years evidence has been increasing that retina development is governed by stochastic processes rather than being tightly regulated. In this context, both the varying numbers of offspring from a single progenitor cell as well as the distributions of final cell fates have been explained using simple probabilistic models. We focus on interkinetic nuclear migration (IKNM), a movement of nuclei between the apical and basal surfaces of the cells in developing pseudostratified epithelia, that was first observed more than 80 years ago. Since, IKNM has been studied in multiple organisms but despite these efforts many questions about the role and precise mechanism of this process remain unsolved. We combine in vivo light sheet microscopy and theoretical models and develop a quantitative description of IKNM in the zebrafish retina. Our findings support the hypothesis of IKNM as a stochastic process. Given that IKNM has been suggested to play a regulatory role in cell differentiation, these results have important implications for understanding the organisation of developing vertebrate tissues.