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BP: Fachverband Biologische Physik

BP 7: Focus Session: Statistical Physics-Based Methods in Molecular Evolution - organized by Alexander Schug and Martin Weigt (joint session BP/DY)

BP 7.1: Invited Talk

Monday, March 12, 2018, 15:00–15:30, H 2013

Evolution of quantitative traits and non-equilibrium matrix ensembles — Simone Pompei, Torsten Held, and •Michael Lässig — Institute for Theoretical Physics, University of Cologne

Evolution affects molecular quantitative phenotypes, such as stability, binding affinities, and metabolic activities of cellular proteins. Linking sequence data to phenotypic and functional changes remains a critical gap in our understanding of evolutionary processes. In this talk, we present new methods to infer a priori unknown quantitative phenotypes from their correlation signature in time-resolved sequence data, using non-equilibrium statistical mechanics and random matrix theory. We use these methods to map the phenotypic evolution of the human influenza virus.