Berlin 2018 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 12: Focus: Molecularly Functionalized Low-Dimensional Systems II - organized by Antonio Setaro, Carola Meyer, Aravind Vijayaraghvan and Matteo Mannini
CPP 12.5: Vortrag
Montag, 12. März 2018, 16:15–16:30, C 130
Impact of chemical treatment of diamond thin films on neuron growth — Barbora Jakubcová1, Jana Turňová1, Václav Petrák1, Pavel Hubík2, Andrew Taylor2, and •Vladimíra Petráková1,3 — 1Czech Technical University in Prague, Faculty of Biomedical Engineering, Kladno, Czech Republic — 2Czech Academy of Sciences, Institute of Physics, Prague, Czech Republic — 3Free University Berlin, Institute of Experimental Physics, Berlin, Germany
This work compares the impact of molecular functionalization and selected material properties of diamond thin films on the growth of neurons. The ability to form an efficient interface between material and neural cells is a crucial aspect of the construction of neuroelectrodes. Diamond thin films offer material characteristics that could greatly improve the performance of neuroelectrodes. The advantage of diamond is a large variety of material and surface properties. Such a variety of material characteristics can lead to various cellular responses. Here we compare growth and development of primary neural cells on diamond thin films of various morphology, conductivity, and doping with their treatment using several types of molecules commonly used to enhance adhesion and cell growth. We found that the variation of material properties of nanocrystalline diamond film does not have a major influence on the neuron growth but it can be to, some extent, influenced by the type of molecular coating, selection of polymer and its molecular weight. Our findings emphasize the importance of the correct molecular treatment over structural or morphological properties of diamond thin films as a material used to form an interface with primary neurons.