Berlin 2018 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
CPP: Fachverband Chemische Physik und Polymerphysik
CPP 32: Poster Session II
CPP 32.12: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster B
Degradable Microgels by Radical Ring Opening Polymerization (RROP) in Miniemulsion — Larissa Hussmann1,2 and •Andrij Pich1,2 — 1DWI Leibniz Institute for Interactive Materials, Aachen, Germany — 2RWTH Aachen University, Aachen, Germany
Due to their porous structure, water absorption and swelling capability, microgels have been applied in tissue engineering, release systems and coating devices. Especially Poly (N-vinylcaprolactam) (PVCL) microgels are interesting candidate for application in biomaterials due to their biocompatibility. However, in order to synthesize PVCL microgels that are able to release molecules or degrade in controlled way, degradable units need to be integrated into the microgel structure. In this work we follow a new approach that allows incorporation of degradable units into the PVCL chains of the microgel network. In our approach we focus on the copolymerization of VCL and a cyclic ketene acetal, to incorporate a degradable ester function in the polymer backbone, after radical ring opening polymerization (RROP)[1]. Obtained microgels may be suitable to a variety of bio-medical applications, due to their degradability as well as ability to solubilize hydrophobic molecules [2]. Also by varying the copolymer structure of microgel chains, it is expected to control the volume phase transition temperature (VPTT) and swelling of the microgels in aqueous solutions.
[1] Bailey, W.J., Z. Ni, and S.-R. Wu, Journal of Polymer Science: Polymer Chemistry Edition, 1982. 20(11): p. 3021-3030. [2] Shi, Y. and S. Agarwal, e-Polymers. 2015. p. 217.