Berlin 2018 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 32: Poster Session II
CPP 32.9: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster B
Enzymatic synthesis of stimuli-responsive microgels — •Elisabeth Gau1,2, Franziska Flecken1,2, Agnieszka Natalia Ksiazkiewicz1,2, and Andrij Pich1,2 — 1DWI - Leibniz-Institute for Interactive Materials e.V., Forckenbeckstraße 50, 52074 Aachen — 2Functional and Interactive Polymers, Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074 Aachen
Aqueous microgels are highly crosslinked, polymer colloids exhibiting promising properties for many applications in the biomedical field, like softness and stimuli-responsiveness depending on the incorporated monomers.[1,2] The most frequently used method for microgel synthesis is precipitation polymerization. For initiation, mainly thermic initiators like azo- or peroxide-based compounds are used, limiting the possible reactants to thermo stable substances.[2] Enzymatic initiation is a promising alternative to enable the incorporation of thermo instable biomolecules into polymers by decreasing the reaction temperature. Herein, we present the use of a glucose oxidase-based initiator system for the synthesis of aqueous microgels.[3] Glucose oxidase catalyzes the oxidation of β-D-glucose with molecular oxygen to D-glucono-lactone and hydrogen peroxide. Through the addition of ferrous ions (Fe2+), the hydrogen peroxide is cleaved into hydroxyl radicals. These radicals act as initiators for the polymerization reaction.[4]
[1]: Pich et al., Adv. Polym. Sci. 2011, 234, 1-37. [3]: Gau et al., Green Chemistry 2017, accepted. [4]: Johnson et al., Biomacromolecules 2009, 10, 3114-3121.