Berlin 2018 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
CPP: Fachverband Chemische Physik und Polymerphysik
CPP 33: Poster Session III
CPP 33.30: Poster
Dienstag, 13. März 2018, 14:00–16:00, Poster C
Responsive Copolymer-Graphene Oxide Hybrid Microspheres with Improved Drug Release Kinetic — •Izabela Firkowska-Boden1, Fuping Dong1,2, Matthias M. L. Arras1,3, and Klaus. D. Jandt1,4 — 1Chair of Materials Science, Otto Schott Institute of Materials Research, Faculty of Physics and Astronomy, Friedrich-Schiller-University Jena, Löbdergraben 32, 07743 Jena, Germany — 2Department of Polymer Materials and Engineering, College of Materials and Metallurgy, Guizhou University, Guiyang, 550025, China — 3Oak Ridge National Lab, Biology and Soft Matter Division, Oak Ridge, TN 37831, USA — 4Jena Center for Soft Matter (ICSM), Friedrich-Schiller-University Jena, Philosophenweg 7, 07743 Jena, Germany
Polymeric hollow spheres with sizes ranging from the nanometer to the micrometer scale are particularly functional materials owing to their potential application as drug delivery system. In order to control the encapsulation and releasing of drug molecules from the interiors under physiological conditions, smart hollow spheres, which are sensitive to temperature have been reported. In this study we aimed to integrate both high loading efficiency and controlled drug release into a hybrid composite material composed of thermoresponsive copolymer hollow microspheres poly(N-isopropylacrylamide-co-styrene) (PNIPAAm-co-PS ) and outer graphene oxide layer. The diffusion-driven drug release is controlled by the electrostatically deposited layer of GO nanosheets, which effectively suppresses the initial burst release and enables sustained drug release in in vitro testing.