Berlin 2018 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 70: Crystallization, Nucleation and Self-Assembly II
CPP 70.9: Vortrag
Donnerstag, 15. März 2018, 17:30–17:45, C 230
Biomolecule-Linked Plasmonic Nanoclusters as Colloidal SERS Sensors — •Roland Paul Maximilian Höller1, Izabella Jahn2, Dana Cialla-May2, Jürgen Popp2, Munish Chanana3, Christian Kuttner1,4, and Andreas Fery1,4 — 1Leibniz Institute of Polymer Research, 01069 Dresden, Germany — 2Leibniz Institute of Photonic Technology, 07745 Jena, Germany — 3Institute of Building Materials, ETH Zürich, 8093 Zürich, Switzerland — 4Cluster of Excellence Centre for Advancing Electronics Dresden and Technische Universität Dresden, 01062 Dresden, Germany
We present controlled three-dimensional nanoassemblies with core/satellite architecture as colloidally stable probes for surface-enhanced Raman scattering (SERS). Aiming at obtaining a versatile system for bioapplications with both high and robust SERS performance, we used BSA as biomolecular linker for the controlled fabrication of self-assembled nanoclusters with correlated optical and structural properties by design [1]. The SERS performance of the assembled nanoclusters was benchmarked using an aromatic low-molecular-weight model analyte (4MBA). The characteristic signals of adsorbed 4MBA were detected with high robustness. The limit of detection of 10-6 M 4MBA was determined using non-enhanced volume-Raman signals of the medium as reference [2]. For bioapplication of such nanoassemblies, the aspects of biocompatibility, cellular uptake, and biological are decisive for a rational material design.
[1] R. P. M. Höller et al., ACS Nano, 2016, 10, 5740. [2] R. P. M. Höller et al., manuscript in preparation.