Berlin 2018 – wissenschaftliches Programm
Bereiche | Tage | Auswahl | Suche | Aktualisierungen | Downloads | Hilfe
DY: Fachverband Dynamik und Statistische Physik
DY 3: Complex Fluids and Colloids I (joint session CPP/DY)
DY 3.4: Vortrag
Montag, 12. März 2018, 10:15–10:30, C 264
PFA-PEG particles: A colloidal model system for the investigation of phase diagrams of PEGylated drug carrier systems — •Marcel Werner1,2, Judith Ruland2, Nils von Seggern1, Moritz Tappe1, Melanie Wernet2, Gabriela Schmidt2, and Eckhard Bartsch1,2 — 1Department of Macromolecular Chemistry, University of Freiburg, Freiburg im Breisgau, Germany — 2Department of Physical Chemistry, University of Freiburg, Freiburg im Breisgau, Germany
Pegylated particles like proteins, peptides and lipid- or polymer-based nanoparticles are known as potential drug delivery systems (DDS) or as nano drug carriers (NDC) [1]. Current research deals with e.g. completely new systems [2], shape effects [3] or the influence of the PEG density on the biocompatibility [4]. However, the phase behaviour of the DDS is not really covered. In an attempt to close this gap we synthesised a new model system, consisting of a highly fluorinated core and a sterically stabilizing PEG-shell [5]. With these particles and different light scattering techniques as well as other complementary techniques such as microscopy and rheology, we gained first insights into the phase behaviour of PEGylated particles. Our findings can lead to higher concentrated carrier systems without unwanted inter particle interference and new formylations e.g. gels or cremes.
[1] T. M. Allen et al., Science, 2004, 303, 1818. [2] E. Ruiz-Hernandez et al., Polym. Chem., 2014, 5, 1674. [3] Y. Li et al., Nanoscale, 2015, 40, 16631. [4] J. L. Perry et al., Nano Lett., 2012, 12, 5304. [5] D. Burger et al., Colloids Surf. A: Physico. Eng. Aspects, 2014, 442, 123.