Berlin 2018 – wissenschaftliches Programm
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DY: Fachverband Dynamik und Statistische Physik
DY 71: Poster: Noneq. Stat. Phys., Stoch. Thermo, Brownian Dyn.
DY 71.11: Poster
Donnerstag, 15. März 2018, 15:30–18:00, Poster A
The Lattice Model of Crowding and Trapping in Line with Experiments in Model Membranes — •Mislav Cvitković1, Marius Glogger2, Markus Engstler2, Susanne Fenz2, and Ana-Sunčana Smith3 — 1Ruđer Bošković Institute, Division of Physical Chemistry, CLS Group, Zagreb, Croatia — 2Universität Würzburg, Biocenter: Department of Cell and Developmental Biology, Germany — 3FAU Erlangen–Nürnberg, Institute for Theoretical Physics, PULS Group, Germany
Lateral diffusion of proteins in biological membranes is a fundamental process that is, in living cells, affected both by protein crowding and intermolecular interactions. To account for these effects, we use a 2D lattice gas of hard particles that interact with ensemble of randomly localized traps. We characterize the behaviour of the system on all time scales, and provide an explicit expression for the long time diffusion coefficient as a function of relevant system parameters. Furthermore, we analyse traces from single–molecule experiments on GPI–anchored Variant Surface Glycoproteins (VSGs) that were purified from Trypanosoma brucei and reconstituted into supported lipid bilayers. VSGs are found to occur in two conformations [Bartossek et al., Nature Microbiology 2:1523 (2017)] and their obstructed diffusion in experiment is found to have similar features to those predicted by the lattice gas model in a broad range of concentrations of VSG.