Berlin 2018 – wissenschaftliches Programm
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MA: Fachverband Magnetismus
MA 33: Biomedical and molecular magnetism
MA 33.11: Vortrag
Mittwoch, 14. März 2018, 17:45–18:00, H 1012
Investigation of uptaking Aminosilane coated magnetite nanoparticles by cells — •m. youhannayee1, s. nakhaeirad2, f. haghighi2, r. ahmadian2, a. shaaban3, j. nothacker3, a. schmidt3, a. barbian4, k. klauke5, c. janiak5, r. rabenalt6, p. albers6, and m. getzlaff1 — 1angewandte physik, heinrich-heine universität, Düsseldorf — 2biochemie molekularbiologie II, HHU — 3Physikalische Chemie, Universität zu Köln — 4Anatomie I, HHU — 5bioanorganische Chemie, HHU — 6Klinik für Urologie, HHU
The basic principle of hyperthermia for cancer therapy arises from increasing the temperature of the specific organs and tissues from 41 °C to 46 °C[1]. Using magnetic nanoparticles and applying alternating magnetic field (AC) on them is so called as magnetic fluid hyperthermia. In this project superparamagnetic iron oxide nanoparticles (SPION) with functionalized surface Aminosilane around the iron oxide core are applied which have been widely using in different experimental applications in vivo and vitro experiments because of biocompatibility and low toxicity of these particles. In order to characterize the morphological properties of SPION variety of measurements and evaluations were carried out such as transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FTIR). Additionally the effect of AC magnetic field on particles was observed. To investigate the effect of magnetic nanoparticles on cells and their uptaking by cells TEM, MTT measurement and flow cytometry (FACS) were carried out. [1] A. Jordan, R. Scholz, P. Wust, H. Fähling, R. Felix. JMMM 201 (1999): 413-419.