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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 12: Poster II

BP 12.32: Poster

Dienstag, 2. April 2019, 14:00–16:00, Poster B2

Computer simulations of SAS-6 assembly on surfaces — •Dennis Wörthmüller1,2 and Ulrich Schwarz1,21Institute for Theoretical Physics, Heidelberg — 2Bioquant, Heidelberg

The scaffold protein SAS-6 self-assembles into a 9-fold ring that forms the structural basis for centrioles and thus is essential for many important cellular processes, including cell division and the genesis of cilia and flagella. Recently the self-assembly of SAS-6 has been studied by high-speed AFM on mica surfaces (Niervergelt et al., Nature Nanotechnology 13:696-701, 2018). Motivated by this experimental study, we have developed a 2D Brownian dynamics simulation model to identify possible assembly pathways, including malformed structures. Our main finding is that strong fluctuations, which are suppressed by the interaction with the surface, lead to malformed structures. Fluctuations also result in a distribution of ring sizes that favors 8-rings over 10-rings.

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