Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 12: Poster II
BP 12.41: Poster
Dienstag, 2. April 2019, 14:00–16:00, Poster B2
Small-angle X-ray Scattering on Photo-switchable Lipid Membranes — •Martina Ober1, Patrick Urban1, Stefanie Pritzl1, David Konrad2, Dirk Trauner2,3, Theobald Lohmüller1,3, and Bert Nickel1,3 — 1Department of Physics, and Center for Nano Science, Ludwig-Maximilians-Universität, Munich, Germany — 2Department of Chemistry and Center of Integrated Protein Science, Ludwig-Maximilians-University, Munich, Germany — 3Nanosystems Initiative Munich, Germany
Light-switchable lipids which are prepared by incorporation of a photo-sensitive azobenzene into a phosphatidylcholine (Azo-PC) enabled a novel approach to study and control the properties of membranes. Azo-PC undergoes a reversible photo-isomerisation of cis- and trans-state on irradiation with UV, respectively visible light, which is well understood on the molecular level. The photo-isomerisation induces a configurational change in the lipid which further affects the overall structure of an Azo-PC membrane. Here, we use small-angle x-ray scattering (SAXS) to perform structure analysis and phase behaviour studies of Azo-PC membranes in a physiological environment. Our research will help to extend the molecular control of photo-switchable lipids to a control of photo-switchable membranes in order to investigate membrane perforation, drug release, and membrane enzyme activity.