Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 12: Poster II

BP 12.64: Poster

Dienstag, 2. April 2019, 14:00–16:00, Poster B2

Characterization of Magnetic Field Generating Tips for Spatio-Temporally Controlled Manipulation of Magnetic Nanoparticles — •Mohammad R. Safari and Cornelia Monzel — Experimental Medical Physics, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany

The manipulation of magnetic nanoparticles is a powerful approach to probe and actuate biological functions in living systems and bears high potential for future medical applications. In comparison to complementary approaches involving chemical and electrical field manipulation, magnetic fields bear the advantage of applying a remote and spatio-temporally defined stimulus, which is nondestructive in the context of a biological sample. In view of realizing the manipulation of single cell functions, we here utilize micrometer magnetic tips to take advantage of their high spatial flexibility, variability in shape, and hence the possibility to dynamically tune magnetic fields and forces. We combine experimental magnetic nanoparticle tracking with in vitro attraction assays and finite element modeling, in order to obtain a comprehensive understanding of the magnetic forces applied ( ~ 10fN). Via systematic characterization of a library of different magnetic tips, we assess their suitability for nanoparticle manipulation approaches on submicrometer scales.