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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 17: Statistical physics of biological systems I (joint session BP/DY)

BP 17.5: Vortrag

Mittwoch, 3. April 2019, 16:15–16:30, H4

Three-dimensional membrane confinement and geometry dictate excitable signaling dynamics in Dictyostelium cells. — •Marcel Hörning1,2,3 and Tatsuo Shibata21Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, 70569 Stuttgart, Germany — 2Laboratory for Physical Biology, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan — 3Institute for Integrated Cell-Material Sciences, Kyoto University, 606-8501, Kyoto, Japan

Propagating waves on the plasma membrane mediate the membrane protrusive activities in Dictyostelium and mammalian cells. Most studies focus on the dynamics extracted from single focal planes only. Thus, the relation between the dynamics and three-dimensional cell shape remains elusive, due to the lack of signaling information about the unobserved part of the membrane.

We show that PtdInsP3 wave dynamics are directly regulated by the three-dimensional geometry - size and shape - of the plasma membrane. By introducing an analysis method that extracts the three-dimensional spatiotemporal activities on the entire cell membrane, we show that PtdInsP3 oscillatory waves self-regulate their dynamics within the confined membrane area. This leads to changes in speed, orientation and pattern evolution, following the underlying excitability of the signal transduction system. This findings emphasize the role of the plasma membrane topology in reaction-diffusion driven biological systems and indicate its importance in other mammalian systems.

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