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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 23: Biomaterials and biopolymers I (joint session BP/CPP)

BP 23.6: Vortrag

Donnerstag, 4. April 2019, 10:45–11:00, H10

Heated microbubbles condense and encapsulate prebiotic molecules and enhance ribozymatic activity — •Matthias Morasch1, Alan Ianeselli1, Alexandra Kühnlein1, Saidul Islam2, Kristian Le Vay3, Hannes Mutschler3, Matthew W. Powner2, Christof B. Mast1, and Dieter Braun11Systems Biophysics, LMU Munich, Amalienstrasse 54, 80799 München — 2Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK — 3Max-Planck Institute for Biochemistry, Am Klopferspitz 18, 82152, Martinsried, Germany

Interfaces in an otherwise homogeneous system can drastically change local reaction dynamics. Here, we studied microscale water cycles by the application of a temperature gradients to microbubbles in water and found that it triggered a wide range of processes crucial for the origin of life. We could show that biomolecules increase in concentration more than 1000-fold by the capillary flow at the air-water interface. RNA precursors are found to crystallize around the bubble, allowing for a possible enantiomeric selection, while monomers undergo an enhanced phosphorylation. In the presence of vesicles, nucleic acids are concentrated and encapsulated in vesicle clusters, which are frequently ejected into the bulk solution. In addition, self-complementary RNA is demonstrated to form sequence-pure hydrogels, while the catalysis of the hammerhead ribozyme drastically increased at the interface compared to the bulk. The studied setting is hypothesized to be ubiquitous on early Earth.

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