Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 24: Cell adhesion and migration, multicellular systems I

BP 24.2: Vortrag

Donnerstag, 4. April 2019, 10:00–10:15, H11

Mechanics of tissue competition: Interfaces stabilize coexistence — Nirmalendu Ganai^1,2, •Tobias Büscher¹, Gerhard Gompper¹, and Jens Elgeti¹ — ¹Theoretical Soft Matter and Biophysics, Institute of Complex Systems, Forschungszentrum Jülich, 52425 Jülich, Germany — ²Department of Physics, Nabadwip Vidyasagar College, Nabadwip, Nadia 741302, India

Cells grow and divide, which implies a change in volume. In physical terms, the conjugate force to a change in volume is pressure. Thus, in order to grow, cells must exert mechanical pressure on the neighbouring tissue. In turn, mechanical stress influences growth. This effect leads to a mechanical contribution when tissues compete for space. The tissue with higher homeostatic pressure, i.e. the pressure at which cell division and death balance, overwhelms the weaker one [2,3,4]. We expand these works to include different adhesion properties. Surprisingly, a weaker tissue can persist in stable coexistence with a stronger tissue, if adhesion between them is small enough. An analytic continuum description can quantitatively describe the underlying mechanism and reproduce the resulting pressures and cell-number fractions. Computer simulations furthermore display a variety of coexisting structures, ranging from spherical inclusions to a bicontinuous state.

[1] Ganai et al, 2018, arXiv:1809.10990

[2] Basan et al, 2011, Phys. Biol. 8, 026014

[3] Podewitz et al, 2016, EPL 109, 58005

[4] Podewitz et al, 2016, New J. Physics 18, 083020