Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Cell adhesion and migration, multicellular systems I
BP 24.7: Vortrag
Donnerstag, 4. April 2019, 11:30–11:45, H11
Mechano-response and multicellular organization — •Sara Kaliman1, Carina Wollnik2, Damir Vurnek1, Diana Dudziak3, Florian Rehfeldt2, and Ana-Suncana Smith1 — 1PULS group, Theoretical Physics I, Friedrich-Alexander-University, Erlangen — 23rd Institute of Physics - Biophysics, Georg-August-University, Göttingen — 3Department of Dermatology, University Hospital, Friedrich-Alexander-University, Erlangen
Today, we know that mechano-response is one of the key regulators of a number of biological processes, including morphogenesis, cell differentiation and cancer progression. However, while there is good understanding of these effects in isolated cells, mechano-sensitivity in tissues remains heavily debated, and it remains unclear if tissue formation and individuals cells in a tissue are affected by surrounding rigidity. Here we show that mechano-response of multi-cellular colonies affects cell density in a steady state (homeostasis) as well as the cell density distribution within the colony. On the cellular level, decreasing substrate rigidity modulates cell proliferation and focal adhesions and induces switch from cuboidal to tubular epithelial structure. Surprisingly, despite strikingly different cell densities, different steady states are characterized by the same morphological features. On the other hand, tissues which are not in the steady state have different morphological properties. These results unequivocally relate cellular and macroscopic lengths scales in a tissue mechano-response.