Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 24: Cell adhesion and migration, multicellular systems I
BP 24.9: Vortrag
Donnerstag, 4. April 2019, 12:00–12:15, H11
Crawling to rolling: adhesion of malaria-infected red blood cells in shear flow — •Anil Kumar Dasanna1 and Ulrich Sebastian Schwarz2 — 1Institute of Complex Systems (ICS-2), Forschungszentrum Jülich, Jülich, Germany — 2BioQuant & Institute for Theoretical Physics, Heidelberg University, Heidelberg, Germany
During malaria infections, the adhesion of infected red blood cells (iRBC) in hydrodynamic flow is an essential step for parasite survival. The gradual change in morphology, stiffness and adhesiveness that takes place over the 48 hour cycle in the blood leads to complex adhesion dynamics in flow such as crawling, flipping and rolling. Earlier we have employed multiparticle collision dynamics for hydrodynamics combined with a deformable red blood cell model for simulating iRBC-adhesion in shear flow [1]. We now show that constant stiffening and change in the morphology drives the cells to unstable adhesion states whereas growth in the number of knobs works in the reverse direction, resulting in middle-stage infected cells to achieve stable adhesion in flow with maximum contact area with the substrate, which is essential for increasing the residency time in the vasculature. We summarize our findings in a phase diagram.
[1] Christine Lansche, Anil K. Dasanna et al., The sickle cell trait affects contact dynamics and endothelial cell activation in Plasmodium falciparum-infected erythrocytes, Nature communications biology 2018 (in press).