Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 31: Cell adhesion and migration, multicellular systems II

BP 31.4: Vortrag

Freitag, 5. April 2019, 10:30–10:45, H10

Rotating lamellipodium waves prior to cell polarization — Cody Reeves^1,2, Benjamin Winkler³, Igor S. Aranson^2,4, and •Falko Ziebert⁵ — ¹Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, USA — ²Materials Science Division, Argonne National Laboratory, USA — ³Physikalisches Institut, Albert-Ludwigs-Universität Freiburg, Germany — ⁴Department of Biomedical Engineering, Pennsylvania State University, University Park, USA — ⁵Institute for Theoretical Physics, Heidelberg University, Germany

Cellular protrusion and lamellipodium waves are widespread and observed for many cell types. They are involved in the cells' exploration of the substrate, their internal organization, as well as for the establishment of self-polarization prior to the onset of motion. Here we apply a recently developed phase field approach to model shape waves and their competition on the level of a whole cell. We derive analytic descriptions for the emergence of a single wave deformation. Further we develop an amplitude equation approach to study competition of multiple waves, describing how cells can transition from a non-moving state towards a polarized, steady moving state. Reference: C. Reeves et al., Comms. Phys. 1,73 (2018).