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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Poster I

BP 6.30: Poster

Montag, 1. April 2019, 17:30–19:30, Poster B2

Influence of extracellular vimentin on cell migration — •Divyendu Goud Thalla1 and Franziska Lautenschläger1,21Cytoskeletal Fibers, INM-Leibniz-Institut für Neue Materialien gGmbH, Saarbrücken,Germany — 2Experimental Physics, Saarland University, Saarbrücken, Germany

Vimentin is a cytoskeletal protein of the family of intermediate filaments which plays a role in cell migration, adhesion and signaling. Apart from its presence in the cytoplasm, it is also found in the extracellular spaces around cells. Secreted vimentin controls inflammation by reducing the neutrophil infiltration, helps in bacterial elimination and consequently triggers the oxidative metabolites in activated macrophages.It promotes axonal growth in astrocytes by activating IGF1 receptors in the same signaling pathway as IGF1. The IGF1/IGF1-R pathway plays a significant role in general cellular functions such as cell migration, proliferation, adhesion and invasion. In this study, we demonstrate the functional similarities of extracellular vimentin and IGF1 in context with these cellular functions. Using a MTT proliferation assay, we show that extracellular vimentin increases the proliferation rate in MCF-7 cells. Furthermore, we carried out wound healing assays suggesting that extracellular vimentin promotes MCF-7 cell migration. In future, we plan to investigate the role of extracellular vimentin in adhesion and invasion to show if it has a similar role in these cellular functions. Consequently, it might be useful for altering and stimulating these cellular functions which would open up the possibility for treating various disease conditions.

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