Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 6: Poster I
BP 6.38: Poster
Montag, 1. April 2019, 17:30–19:30, Poster B2
Acoustic wave irradiation of cancer cells — •Lena Fastenrath1, Maja Strugacevac1, Tobias Löffler1, Constanze Wiek2, Julia Kristin2, Jörg Schipper2, and Mathias Getzlaff1 — 1Heinrich-Heine-Universität Düsseldorf, Institute of Applied Physics, Universitätsstr. 1, 40225 Düsseldorf, Germany — 2Düsseldorf University Hospital, Department of Otorhinolaryngology, Moorenstrasse 5, 40225 Düsseldorf, Germany
Our group is developing new, alternative, cell-selective treatment strategies for squamous cell carcinoma cells of the head-neck area. This therapy is based on the different mechanical properties of oral keratinocytes and cancer cells.
Squamous cell carcinoma cells were exposed in vitro to sound waves exhibiting frequencies between 0.5 kHz and 10.0 kHz. For those frequencies that have lead to the strongest cell reaction we varied input voltage and the distance between the cells and the sound probe.
The reaction and the change of areal extent of the cells were observed under a fluorescence confocal laser scanning microscope. Our latest results will be presented and discussed.