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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Poster I

BP 6.44: Poster

Montag, 1. April 2019, 17:30–19:30, Poster B2

First evidence of cellular uptake of environmentally relevant microplastic particles — •Anja Ramsperger1,2,4, Bangalore Vinay Kumar1,4, Wolfgang Gross2,4, Holger Schmalz3,4, Holger Kress2,4, and Christian Laforsch1,41Animal Ecology I and BayCEER — 2Biological Physics Group — 3Macromolecular Chemistry II and BPI — 4University of Bayreuth, Germany

Research efforts on microplastic (MP) pollution is strongly increasing during the last 15 years. Plastic introduced to the environment undergoes processes of degradation and disintegrates to MP. Furthermore, microbes attach to MP surfaces and, together with biomolecules, form an ecocorona that can enhance the ingestion of MP by organisms. Once ingested there is evidence that MP can harm organisms for example by translocating into tissue causing e.g. inflammatory responses. The processes involved in the translocation of MP into tissue are not known and to our knowledge a process for cellular uptake of environmentally relevant MP was not described to date. Therefore, we investigated the cellular uptake of MP and show that MP from environmental media gets internalized by murine macrophages significantly more often than control MP. To unravel which surface properties might trigger internalization into cells, we are currently analyzing the composition of the ecocorona on MP by using SEM and micro-Raman spectroscopy. A quantification and characterization of the internalization of environmentally relevant MP by cells will likely be an important step for understanding the potential subsequent translocation into tissue and inflammatory responses which can harm the whole organism.

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