Regensburg 2019 – wissenschaftliches Programm
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BP: Fachverband Biologische Physik
BP 6: Poster I
BP 6.50: Poster
Montag, 1. April 2019, 17:30–19:30, Poster B2
Myosin-dependent mechanosensory adaptation in Drosophila — •Chonglin Guan1, Kengo Nishi1, Christian Kreis2, Oliver Bäumchen2, Martin Göpfert3, and Christoph F. Schmidt1,4 — 1Drittes Physikalisches Institut - Biophysik, Fakultät für Physik, Georg-August-Universität Göttingen, 37077 Göttingen — 2Max-Planck-Institut für Dynamik und Selbstorganisation, 37018 Göttingen — 3Abteilung Zelluläre Neurobiologie, Schwann-Schleiden-Forschungszentrum, Georg-August-Universität Göttingen, 37077 Göttingen — 4Department of Physics, Duke University, Durham, NC 27708, USA
Mechanosensory receptor cells detect and convert a diverse range of physical forces such as sound, vibration and stretch into biological (electrical) signals. The fruit fly Drosophila melanogaster possesses specialized organs, chordotonal organs (ChO), to "hear" external sound, feel airflow and keep track of body motions (propiosensing). Mechanoelectrical transduction in these organs is typically controlled by active, force-generating processes (adaptation motors). The nature of those force generators, however, is not known. We have combined electrophysiological analysis with mechanical stimulation, and have correlated mechanical properties and active manipulation with neuronal activity. We show that non-muscle myosin II activity in ChOs of Drosophila larvae is responsible for both mechanosensoy adaptation and neuronal responsiveness. Mechanical experiments suggest that elasticity and pretension in the ChO's depend on the activities of myosin motors.