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Regensburg 2019 – wissenschaftliches Programm

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BP: Fachverband Biologische Physik

BP 6: Poster I

BP 6.59: Poster

Montag, 1. April 2019, 17:30–19:30, Poster B2

Influence of Intermediate Filaments on Microtubule Dynamics and Organisation — •Laura Schaedel, Charlotta Lorenz, Susanne Bauch, and Sarah Köster — Institut für Röntgenphysik, Universität Göttingen

The cytoskeletal networks are involved in fundamental cellular functions such as the control of cell shape and mechanics. They are composed of different types of biopolymers that have substantially distinct mechanical, structural and biochemical properties. These contrasting characteristics make the study of the interactions between the cytoskeletal subsets interesting, as cells are likely to regulate and combine them in a coordinated manner in order to efficiently carry out diverse processes. Here, we study the direct interaction between two major components of the cytoskeleton - vimentin filaments, one of the most abundant members of the intermediate filament family, and microtubules - in a reconstituted in vitro setup. We build different vimentin network architectures and characterise their impact on microtubule dynamics and mechanics. With our minimalist approach, we aim at better understanding the fundamental properties of vimentin-microtubule composite network architectures and self-organisation.

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DPG-Physik > DPG-Verhandlungen > 2019 > Regensburg