Regensburg 2019 – wissenschaftliches Programm
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CPP: Fachverband Chemische Physik und Polymerphysik
CPP 58: Nanostructures, Nanostructuring and Nanosized Soft Matter
CPP 58.3: Vortrag
Donnerstag, 4. April 2019, 15:45–16:00, H13
Research of the high loading capacities of amphiphilic Poly(2-Oxazoline)-based Triblockcopolymers with Curcumin — •Özgür Düdükcü1, B. Sochor1, M. Lübtow3, B. Schummer1,2, R. Luxenhofer3, and R. Hanke1,2 — 1Institute of Physics, Chair of X-ray Microscopy, Universität Würzburg, Germany — 2Fraunhofer Insitiute for Integrated Circuits IIS, Development Center X-ray Technology EZRT, Fürth, Germany — 3Functional Polymer Materials, Chair for Advanced Materials Synthesis, Department of Chemistry and Pharmacy and Bavarian Polymer Institute, Universität Würzburg, Germany
In this project, drug-loaded triblock copolymers in solu- tions were investigated using small-angle-neutron-scatter- ing (SANS), densiometric measurements and 1H-NMR Spectro- scopy. Curcumin was used as the hydrophobic drug and Poly (2-Oxazoline)-based amphiphilic triblock copolymers as carrier systems. The triblock copolymers consist of a hydrophobic middle block and hydrophilic side chains. Polymer carrier systems in nanomedicine typically have loading capacities of less than 10-20 %. The aim of the project was to clarify the high drug loading capacities up to 80 wt% of the investigated formulations. This effect is still unexplained. By analysing the scattering curves of the formulations resulting from the SANS experiments, information about the structure and composition of the formulations was obtained. The scattering curves are compared with theoretical models to clarify the structure of formulated drug-polymer-systems. The analysis showed that the drug-loaded polymers form micelles with a hydrophobic core and two outer shells, i.e. a core-shell-shell model. Including 1H-NMR measurements it was found that curcumin does not only accumulate in the hydrophobic core. Despite its hydrophobic character interacts with the hydrophilic side chains of the triblock copolymer and forms a second shell. Thus this model gives a possible explanation of the high loading capacity of the polymers.